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. 2022 Feb 23;26:100776. doi: 10.1016/j.neo.2022.100776

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© 2022 Published by Elsevier Inc.

This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).

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Fig 1 — Expression of XPO1 in NB. (A) Comparison of XPO1 levels in normal adrenal gland (AG), neural crest (NC), and NB show significantly higher levels in NB (P = 3.0e-35; one-way ANOVA). (B) Analysis of XPO1 expression demonstrate higher expression levels in NB compared to acute lymphoblastic (ALL) and acute myeloid leukemia (AML), rhabdoid tumor (RT), or Wilms’ tumor (WT; P < 0.001; Kruskal-Wallis test). (C) (D) Survival analysis of 649 patients with NB published by Kocak et al.²⁷ by their XPO1 expression. Using an expression cutoff of 13,893, patients fare worse if they have high XPO1 expression levels. Log-rank test with Bonferroni correction. (E) Drug sensitivity assays with 7 human and one murine NB line (NSX-2). Intermediate responders are marked in blue and good responders in red; mean values and standard deviation of technical triplicates. One set of two biological replicates is shown. The graphs in subpanel C and D were generated using the r2 platform (https://hgserver1.amc.nl/cgi-bin/r2/main.cgi).