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. 2022 Feb 2;58:101453. doi: 10.1016/j.molmet.2022.101453

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© 2022 The Author(s)

This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).

PMC Copyright notice

Noncoding RNAs in sEVs derived from different tissues/cells mediate the progression of diabetes and its complications. sEV noncoding RNAs derived from plasma/urinary tissue have mainly been explored as biomarkers for diabetes and its complications. sEV noncoding RNAs derived from adipose/pancreatic/skeletal muscle/liver/kidney tissue have been proven to have important roles in insulin secretion and sensitivity regulation, whereas BM-MSCs and umbilical cord-derived sEV noncoding RNAs are promising agents for diabetic therapy.