Table 5.
Effect of study medications on serum biomarkers levels.
| Sr. no. | Day 0 | Day 7 | Day 14 | |
|---|---|---|---|---|
| CRP (mg/L) | ||||
| 1 | Add-on group (n = 78) | 40.65 ± 21.85 | 38.98 ± 25.55 | 37.76 ± 21.16 |
| 2 | SOC Group (n = 80) | 40.74 ± 24.29 | 39.31 ± 22.35 | 40.71 ± 22.41 |
| CPK (U/L) | ||||
| 1 | Add-on group (n = 78) | 71.65 ± 49.57 | 68.75 ± 41.75 | 57.23 ± 38.75*,**,# |
| 2 | SOC Group (n = 80) | 72.24 ± 43.71 | 68.98 ± 43.29 | 70.60 ± 42.91 |
| LDH (U/L) | ||||
| 1 | Add-on group (n = 78) | 769.61 ± 336.12 | 688.54 ± 250.50*,@ | 666.68 ± 227.91**,# |
| 2 | SOC Group (n = 80) | 776.98 ± 349.37 | 827.53 ± 316.90 | 767.56 ± 285.35 |
| Ferritin (ng/ml) | ||||
| 1 | Add-on group (n = 78) | 542.52 ± 269.62 | 463.66 ± 242.28** | 454.54 ± 242.56** |
| 2 | SOC Group (n = 80) | 547.47 ± 328.45 | 499.93 ± 279.56 | 457.06 ± 278.51* |
| D-Dimer (μg/ml) | ||||
| 1 | Add-on group (n = 78) | 394.76 ± 343.21 | 325.77 ± 295.81** | 253.48 ± 242.09**,## |
| 2 | SOC Group (n = 80) | 444.95 ± 295.13 | 399.57 ± 266.08 | 355.18 ± 245.53* |
| IL-6 (pg/ml) | ||||
| 1 | Add-on group (n = 78) | 118.64 ± 166.70 | 115.33 ± 169.68 | 85.18 ± 123.02*,## |
| 2 | SOC Group (n = 80) | 212.10 ± 263.47 | 168.46 ± 234.66 | 157.73 ± 189.64* |
*p<0.01 as compared to Day 7; **p<0.01 as compared to Day 1 (Within group).
#p<0.01; ##p<0.001 as compared to Day 14 of SOC Group using Unpaired t test with Welch correction.
@p<0.001 as compared to Day 7 of SOC Group using unpaired t test with Welch correction.