Table 1.
List of S protein mutations in SARS-CoV-2 variants
| GISAID Variant lineage |
Mutations in S protein | GISAID accession number |
|---|---|---|
| Alpha | A570D, D614G, D1118H, H69del, N501Y, P681H, S982A, T716I, V70del, Y145del | EPI_ISL_581117 |
| B.1.1.207 | D614G, E484K, P681H | EPI_ISL_778908 |
| B.1.1.298 | D614G, H69del, I692V, M1229I, V70del, Y453F | EPI_ISL_616802 |
| B.1.2 | D614G, E484K, G446V, Y453F | EPI_ISL_833413 |
| B.1.258 | D614G, H69del, N439K, V70del | EPI_ISL_755592 |
| Beta | A243del, A701V, D80A, D215G, D614G, E484K, K417N, L242del, L244del, N501Y | EPI_ISL_678597 |
| Epsilon | A222V, D614G, L452R, S13I, W152C | EPI_ISL_847764 |
| B.1.494 | A262S, D614G, D796Y, H49Y, L452R, N501Y, P681R, Q613H | EPI_ISL_826591 |
| Gamma | D138Y, D614G, E484K, H655Y, K417T, L18F, N501Y, P26S, R190S, T20N, T1027I, V1176F | EPI_ISL_833136 |
| Delta | Spike T19R, Spike del157/158, Spike L452R, Spike T478K, Spike D614G, Spike P681R, Spike D950N | EPI_ISL_1841283 |
| Kappa | Spike E154K, Spike L452R, Spike E484Q, Spike D614G, Spike P681R, Spike Q1071H | EPI_ISL_1663368 |
| Lambda | Spike G75V, Spike T76I, Spike R246N, Spike del247/253, Spike L452Q, Spike F490S, Spike D614G, Spike T859N | EPI_ISL_2921276 |
| Mu | Spike T95I, Spike Y144S, Spike Y145N, Spike R346K, Spike E484K, Spike N501Y, Spike D614G, Spike P681H, Spike D950N | EPI_ISL_2178402 |
SARS-CoV-2 lineage identification and variant naming were obtained from GISAID (https://www.gisaid.org). Mutations in the S protein and the sequence accession number of each isolate are listed.