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. 2021 Dec 13;15(2):327–337. doi: 10.1038/s41385-021-00472-w

Fig. 6. LIGHT activates canonical and alternative NF-κB signaling pathways in esophageal fibroblasts.

Fig. 6

a STRING analysis of molecular signaling-related genes up-regulated by LIGHT in normal esophageal fibroblasts (>1.5 fold, p < 0.05). b Representative western blot (WB) comparing p65 translocation in nuclear vs cytosolic extracts from normal esophageal fibroblasts treated with LIGHT for the indicated times (n = 3). c Representative images of normal or active EoE esophageal fibroblast monolayers stained for p65 after 20 min of LIGHT stimulation (n = 3). d Representative WB comparing p100 cleavage into p52 in whole cell lysates from normal or active EoE esophageal fibroblasts treated with LIGHT for the indicated times (n = 3). Representative images of p65 translocation (e) and representative western blot of p100 cleavage (f) in cells transfected with scramble RNA (siNTC) or siRNAs against HVEM (siHVEM) or LTβR (siLTβR) and untreated or treated with LIGHT for the times indicated (n = 3).