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. 2021 Dec 13;15(2):327–337. doi: 10.1038/s41385-021-00472-w

Fig. 7. NIK inhibition has a dominant suppressive role on LIGHT responses in esophageal fibroblasts.

Fig. 7

Representative images of p65 translocation (a) and representative western blot of p100 cleavage (b) in cells pre-treated with BAY11-7082 or NIK-SMI1 for 1 h and then treated with LIGHT for the times indicated (n = 3). Representative histograms of flow cytometry of ICAM-1, VCAM-1 and CD74 in normal esophageal fibroblasts pre-treated with BAY11-7082 (c) or NIK-SMI1 (d) for 1 h and then treated with LIGHT for 24 h (n = 3). RT-PCR of inflammatory (e) and homeostatic (f) genes in esophageal fibroblasts pre-treated with BAY11-7082 or NIK-SMI1 for 1 h and then treated with LIGHT for 24 h (n = 6). Each colored dot represents fibroblasts from an independent donor. *p < 0.05, **p < 0.01 and ***p < 0.001.