Table 1.

Studies on immunogenicity/ICD potential of different types of RCDs.

Study	ICD inducer	PCD	DAMPs	Other proof of immunogenicity
Casares et al. (2005) [27]	Doxorubicin (DX)	Apoptosis	HMGB1, HSP70
Tesniere et al. (2010) [25]	Oxaliplatin (OXP)	Apoptosis	Ecto-CRT, HMGB1
Panzarini et al. (2014) [26]	Rose Bengal Acetate Photodynamic Therapy (RBAc-PDT)	Apoptosis	Ecto-CRT, ATP, HMGB1, HSP70, and HSP90
Koks et al. (2015) [136]	Newcastle disease virus (NDV)	Necroptosis	Ecto-CRT, ATP, HMGB1, HSP70, and HSP90
Aaes et al. (2016) [56]	Doxycycline (doxy)/doxy + B/B dimerizer	Necroptosis	ATP and HMGB1	DC maturation
Teo et al. (2017) [140]	BYL719 (PI3Ka inhibitor) + LEE011(CDK4/6 inhibitor)	Apoptosis	Ecto-CRT
Hossain et al. (2018) [20]	Dinaciclib	Apoptosis	Ecto-CRT, ATP, and HMGB1
Li et al. (2018) [137]	Doxorubicin-polyglycerol-nanodiamond composites	Apoptosis	Ecto-CRT, HMGB1, and HSP90	DC maturation
Turubanova et al. (2019) [21]	Photosens	Apoptosis and ferroptosis	Ecto-CRT, ATP, and HMGB1	IL-6
Turubanova et al. (2019) [21]	Photodithazine (PD)	Apoptosis	Ecto-CRT, ATP, and HMGB1	IL-6
Efimova et al. (2020) [62]	RAS-selective lethal 3	(Early) ferroptosis	ATP and HMGB1	DC maturation
Franco-Molina et al. (2020) [141]	Panobinostat (PAN)	Apoptosis	HMGB1, HSP70, and HSP90
Franco-Molina et al. (2020) [141]	Lophophora williamsii (LW)	Apoptosis	HMGB1, HSP70, and HSP90
Jeong et al. (2021) [23]	Fluorinated mitochondria-disrupting helical polypeptides (MDHPs)	Apoptosis	Ecto-CRT, ATP, and HMGB1
Villamañan et al. (2021) [142]	Temozolomide (TMZ) + CX-4945 (protein kinase CK2 inhibitor)	Unspecified	Ecto-CRT and ATP
Turubanova et al. (2021) [22]	Porphyrazines (pz I)-PDT	Apoptosis	ATP and HMGB1	DC maturation
Turubanova et al. (2021) [22]	Porphyrazines (pz III)-PDT	Apoptosis and Necroptosis	ATP and HMGB1	DC maturation
Tomić et al. (2021) [24]	Plasma-activated medium (PAM)	Apoptosis		DC maturation