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. 2021 Oct 20;15(2):301–313. doi: 10.1038/s41385-021-00462-y

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 4 — a Extracellular flux was analyzed on HDM-pulsed BMDC isolated from WT (black) and Irg1^−/− (red) mice. A metabolic stress test was performed, and kinetic oxygen consumption rate (OCR) was graphed in response to sequential treatments of oligomycin (Oligo, 1 mM), carbonyl cyanide 4-(trifluoromethoxy) phenylhydrazone (FCCP, 2 mM), and antimycin A/rotenone (0.5 mM) after basal measurements. Each circle represents the mean ± SE (n = 6). b Histogram overlays (left) and bar graph frequencies of MitoSOX^hi CD11c⁺ CD11b⁺ BMDC (right) pulsed with HDM or HDM + STING. qPCR for mRNA expression of (c) antioxidant and (d) metabolic genes. (n = 4–6 per group, *P < 0.05, WT versus Irg1^−/−, unpaired t-test). Data represent the mean ± SD of at least two independent experiments.