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. 2021 Oct 20;15(2):301–313. doi: 10.1038/s41385-021-00462-y

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 6 — a Heatmap of selected top 25 metabolites ranked by t-test (P < 0.05) and b IPA of the unbiased metabolomic analysis of extracted polar metabolites from HDM(100 µg ml⁻¹)-pulsed BMDC treated with or without STING agonist c-di-GMP (10 µM) for 16 h. Quantitation of polar metabolites was performed using positive/negative ion-switching LC-MS/MS with a 5500 QTRAP hybrid triple quadrupole mass spectrometer. Each group contained at least 3 replicate samples. The data set was analyzed using IPA software to obtain a list of the top-selected upregulated and downregulated metabolites in HDM-pulsed BMDC treated with and without STING compared with the unpulsed control.