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. 2022 Jan 31;58:101446. doi: 10.1016/j.molmet.2022.101446

Figure 3.

Figure 3

Adipocyte-specific knockout of survivin impaired the glucose homeostasis when exposed to HFD. (A) The growth curve of SKO and Con mice fed HFD for 16 weeks (n = 7–9 for each group). (B) The food intake during HFD feeding of mice in two groups. (C, D) The tissue weight and the ratio of tissue weight to body weight of Con and SKO mice fed HFD for 16 weeks (n = 6–8 for each group). (E, F) Representative gross appearance and HE staining of iWAT, eWAT, BAT, and liver of Con and SKO mice fed HFD for 16 weeks. (G) The liver triglyceride (TG) contents of Con and SKO mice fed HFD for 16 weeks (n = 6 for each group). (H, I) The intraperitoneal glucose tolerance test (IPGTT) and the insulin tolerance test (ITT) after feeding HFD for 12 weeks and 14 weeks, respectively (n = 6–9 for each group). (J) The thermogenic gene expression of BAT from Con and SKO mice fed HFD for 16 weeks (n = 6–8 for each group). ∗P < 0.05. ∗∗P < 0.01, ∗∗∗P < 0.001.