Table 2.
miRNAs of interest across species.
| Study | Pop. | N | Trauma | Over-expressed MiRNAs | Under-expressed miRNAs | Timepoints | Exosome Source | NDE/ADE/Total |
|---|---|---|---|---|---|---|---|---|
| Devoto et al. (90) | Human Military | N = 73 1–2 TBI, N = 35 control | Blast | miR-3190-3p, 18a-5p, 372-3p, 376b-3p, 382-3p, 375 | miR-139-5p*, 150-5p | ~11 yrs | Plasma | Total |
| Harrison et al. (91) | Mice, M 7–9 wks |
N = 12, 3 pooled samples per group | CC | miR-7a-5p, 7b-5p, 15a-5p, 21a-5p, 130a-3p*, 142a-5p, 146a-5p, 181b-1-3p, 203-3p*, 219a.2-3p |
miR-30e-3p*, 128-2-5p*, 130-b-5p*, 139-3p*, 221-3p, 335-3p*, 361-3p* | 7 days | Brain extract | Total |
| Huang et al. (92) | Mice, M 10–12 wks |
N = 6/group | CCI, Rep TBI | miR-124-3p*, 124-3, 124-2, 128-3p*, 125a-5p, 138-5p, 376b-3p, 335, 382-5p, 434-3p | None | 3, 7, 14, 21, 28 days | Brain extract | ADE |
| Ko et al. (93) | Human civilian | N = 16 TBI, N = 20 control | mild TBI | miR-185-5p, 206 | miR-203a-3p*, 203b-5p | <24 hrs | Plasma | Total |
| Ko et al. (93) | Mice, M 12–14 wks |
N = 56 CCI, 60 Blast, 36 control | Blast, CCI | miRNA-9-5p*, 219a.2-3p, 488-3p | miR-22-5p, 150-5p, 351-3p, 669c-5p, 6236 | 1 h, 1, 4, 14 days | Plasma | Total |
| Gayen et al. (94) | Humans, in vitro | N/A | IL-6 | miRNA-29a, 30d*, 130b*, 139-5p*, 141, 143, 145*, 146a, 194, 203*, 375 | None | 24 h | Human Astrocyte Supernatant | ADE |
| Ge et al. (95) | Mice, M 12 wks |
N = 3 per group | CCI, Rep TBI | miRNA-124-3p* (3 & 14d), 6096-5p | miR-124-3p* (42d), 744-3p, 764-3p, 767, 7046-3p, 7660-3p, 7665-5p, 7674-5p | 3, 14, 42 days | Brain extract | ADE |
| Wang et al. (96) | Rats, M 12–16 wks |
N = 3 per group | Weight drop | miRNA-9a-3p*, 29b-3p, 124-3p*, 142-3p, 181c-3p, 195-3p, 328-5p, 361-3p*, 434-3p, 451-5p, 532-5p | miRNA-9a-5p, 28-3p, 92a-3p, 96-5p, 145-3p*, 221-5p, 222-3p | 24 h | Plasma | Total |
| Guedes (50) | Human Military |
N = 28 control N = 71 mTBI/-PTSD N = 45 mTBI/+PTSD |
mTBI | miR-3190-3p, 615-5p, 1185-1-3p, 3196, 509-3-5p, 204-5p, 372-3p, 1277-3p | miR-139-5p | ~9 yrs | Plasma | Total |
In this table, bolded items represent miRNA identified in multiple studies. Items with an asterisk represent those found to be inversely altered across studies (i.e., over-expressed in one, under-expressed in another). M, Male; CCI, controlled cortical impact. Other abbreviations are as previously defined.