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. 2022 Feb 10;13:803962. doi: 10.3389/fimmu.2022.803962

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Copyright © 2022 Xiao, Liang, Yan, Chen, Zhu, Xie, Li, Li, Gao, Feng, Fu and Gao

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Establishment of a four-MDG signature. (A) Venn diagram showing DEGs and MDGs from the TCGA and ICGC datasets. (B) Volcano plot of DEGs with the four-MDG signature gene marked. (C) Distribution maps showing the degree of methylation degree (the top row) of the four signature genes and their correlation plots (the bottom row) between mRNA expression and DNAm levels. (D) K-M curves for the four MDGs in the TCGA dataset. (E) Univariate Cox regression of the four signature genes in the TCGA dataset. (F) LASSO coefficient profiles of the 35 genes in the TCGA dataset. (G) Selection of the optimal parameter (lambda) in the LASSO model.