Figure 2.

Identification of clinically relevant DNA alterations and molecular subtypes of PDAC PDOs. A, A comparison of molecular subtyping using two algorithms on RNA-seq data from PDOs: Moffitt and DECODER, and IHC on patient tissue and PDOs. B–D, Nuclear staining of GATA6 (classical subtype marker in green) and KRT5/6 and p63 (basal subtype marker in red) expressed in biopsies and PDOs for patients 3, 6, and 19. E, Oncoplot of clinically relevant DNA alterations identified on biopsies using targeted sequencing annotated with relevant clinical parameters.