FIGURE 5.

Middle‐aged (16–19 months old) female Tat(+) mice had greater learning deficits on a radial arm water maze than their Tat(−) counterparts, irrespective of estropausal status (A). Anxiety‐like behavior on an elevated plus maze was greater among peri‐ and post‐estropausal mice compared to those that were pre‐estropausal, irrespective of Tat exposure (B). Male or female Tat(+) mice had reduced grip strength compared to Tat(−) controls. Middle‐aged males (11–13 months old) had reduced grip strength compared to young adult males (6–8 months old) (C). *Significant difference from Tat(−) control. †Significant difference from young adult male or pre‐estropausal female group ¹⁷⁷