Fig. 2.
Rescue of vision after treatment at 12 or 16 weeks of age, but not at 24 weeks. Pde6bSTOP/STOP mice were treated at 12, 16 or 24 weeks of age, and then subjected to the Morris water maze behavioral test (under dim-light conditions) over 5 consecutive days at 40 weeks of age (or 30 weeks for pw12-treated mice). a Escape latency (time to find the hidden platform) and b total path (from starting point to platform)—presented as the mean ± SEM on the left and the area under the curve (AUC) on the right. Asterisks, significance for mutant and treated pw24 vs WT, treated pw12, and pw16. c Representative swimming trajectories for days 1 and 5. d Probe trial; platform was removed from the north target (T) quadrant, and time spent in each quadrant measured. Data presented as mean percentage (± SEM) of time spent in each quadrant; dashed line, chance level (25%). Representative swimming trajectories for the probe trial are shown at the bottom. Asterisks, significance for T vs other quadrants. Tukey’s test for multiple comparisons. **P ≤ .01; *** P ≤ .001. N values indicated in legend next to each group