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. 2022 Feb 23;79(3):148. doi: 10.1007/s00018-022-04161-0

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© The Author(s) 2022

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 5 — Bipolar cell remodeling halted by treatment at 12 and 16 weeks of age, but not at 24 weeks. Pde6b^STOP/STOP mice were treated (or not) at pw12, pw16 or pw24, and analyzed at pw40. Pde6b^STOP/+ mice (WT) were 40 weeks of age. Retinal sections were labeled with a, b anti-PKCα antibody to visualize rod bipolar cells, and d, e anti-secretagogin antibody to visualize cone bipolar cells particularly their processes in the OPL. Sections from a, d untreated Pde6b^STOP/STOP mice, and b, e treated Pde6b^STOP/STOP and Pde6b^STOP/+ (WT) mice. Vertical white bars in a and b, rod bipolar dendrites in the OPL; arrowheads, rod bipolar cells having aberrant dendrites; arrows, ectopic cell body. Schematic representation of healthy c rod bipolar cells and f cone bipolar cells. Scale bars, 10 µm (a, b) and 20 µm (d, e)