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. 2022 Feb 23;79(3):148. doi: 10.1007/s00018-022-04161-0

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© The Author(s) 2022

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 7 — Quantification of acellular capillaries. Untreated Pde6b^STOP/STOP (mutant) and Pde6b^STOP/+ (WT) mice were analyzed at 16, 24, 30, and 40 weeks of age. Pde6b^STOP/STOP mutant mice were treated at 12, 16 or 24 weeks of age, and all analyzed at 40 weeks of age. Whole-mounted retinas were trypsin digested and stained with hematoxylin–eosin. a Representative images of whole retinal vasculature and higher-magnification images—all at 40 weeks of age. Black arrows, acellular capillaries; scale bars, 500 µm (whole retina/low mag) and 25 µm (high mag). b Mean number of acellular capillaries per scan field (± SEM); t test comparing treated mutants vs 40-week-old untreated mutant; n.s. not significant; *P ≤ .05; ** P ≤ .01. N values are provided in the legend next to the groups and in detail in “Materials and methods”