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. 2022 Feb 10;9:790995. doi: 10.3389/fmed.2022.790995

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Copyright © 2022 Schlichtner, Yasinska, Ruggiero, Berger, Aliu, Prunk, Kos, Meyer, Gibbs, Fasler-Kan and Sumbayev.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Effects of TGF-β on Smad4 and TRIM-33 levels and phsopho-Smad3-Smad4 or phsopho-Smad3-TRIM33 interactions in a variety of rapidly proliferating human cells. Jurkat T, THP-1, MCF-7 and HaCaT cells were exposed to 2 ng/ml TGF-β for 24 h followed by Western blot detection of Smad4/TRIM-33 levels as well as ELISA-based analysis of phospho-Smad3-Smad4 or phospho-Smad3-TRIM33 interactions. Images are from 1 experiment representative of 4 which gave similar results. Quantitative data represent mean values ± SEM of 4 independent experiments. * p < 0.05 and ** p < 0.01 vs. control.