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. 2022 Feb 19;14:43–57. doi: 10.2147/ORR.S348919

Table 1.

Overview of the Similarities and Differences Between a Seroma and Hematoma in the Setting of TJA

Seroma Hematoma
COMPOSITION Serous exudate (lymph, fibrin, WBC, cytokines) Scant Blood Products Majority of Blood products, (RBC, fibrin, platelets, cytokines)
TIMEFRAME TO APPEARANCE 2 weeks or more 2–7 days
ASSOCIATED LABS Loosely associated with Nutrition labs* Declining hemoglobin and Hematocrit
PHYSICAL EXAM FINDINGS Fluid Wave Firm Mass; Ecchymosis
COMMON LOCATION(S) Subcutaneous tissue superficial to muscle fascia Subcutaneous tissue superficial to muscle fascia; superficial to muscle by deep to fascia; intramuscular; intra-articular
ULTRASOUND Anechoic Hyperechoic
CT SCAN 0–20 Hounsfield Units Hounsfield Units:
30–45 (uncoagulated)
60–100 (coagulated)
*CT Angiography to help identify bleeding vessel
MRI Hypointense T1
Hyperintense T2 & STIR
Septations, fluid-fluid levels
Hyperintense T1 & T2 & STIR
APPEARANCE OF ASPIRATION FLUID Translucent yellow-orange serous Early hematoma dark red *Difficult to aspirate mature coagulated hematoma