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. 2022 Feb 23;7:25. doi: 10.1038/s41541-022-00444-6

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 4 — Power calculated by exact method, based on binomial distribution of cases in investigational group among overall number of cases. Attack rate representing the frequency of events is assumed in control group - Type I error 2.5% - 1:1allocation ratio. Selected attack rates reflect the range of incidence rates of events as estimated in our study (IR 1000/100,000 individuals = attack rate of 1%).