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. 2022 Feb 23;13(2):174. doi: 10.1038/s41419-022-04624-z

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 1 — A Venn diagram and heatmap revealing the identification of downregulated genes in GSK-J4-treated NB cell lines using the public dataset (GSE110709) and our previous microarray study (GSE180601). B Western blot indicating the expression of SAPCD2 in SH-SY5Y treated with 0.5 μM GSK-J4 and SK-N-BE(2) treated with 1 μM GSK-J4 for time points as indicated. C. Kaplan–Meier curves indicate the survival of NB patients with high or low SAPCD2 expression. D Public datasets reveal the differential expression of SAPCD2 transcript in NB tissues with different status of death, progression, or risk of progression. E Public database revealing the copy number and genetic variants of MYCN and SAPCD2 gene in NB tissues with different status of death. F, G Representative immunohistochemical staining and immunohistochemistry scores revealing SAPCD2 expression in NB tissues and normal peripheral nerve tissues (PT). Scale bars, 100 μm. H GO analysis of the top 50% of genes (n = 2311 genes) that tightly co-expressed with SAPCD2. FDR <0.05. I Scatter plot shows a positive significant correlation between SAPCD2 transcript levels and CIN scores in NB tissues. J SAPCD2 expression levels relative to the indicated tumor types and normal samples from the TCGA dataset. K Bubble plot showing levels of correlation between SAPCD2 transcript levels and CIN scores in indicated tumor types from the TCGA dataset. Log-rank test for analysis in C; unpaired two-sided t-test in D, E, G, and J, data were shown as mean ± SD (error bars); Pearson’s correlation coefficient in I and K. ns, not significant. Data were representative of three independent experiments in B.