Fig. 4. Functional Hierarchies in Model Input.

a We found the explanatory power on test data to decrease as the number of TFs were removed from the model. Particularly, we found around 500 TFs to carry a greater predictive power, as the explanatory power after that point more rapidly decreased. b We measured the median number of scientific studies at each iteration of our backward-selection algorithm, and found that as the number of input TFs decreased, the more studied were those that were left. c The TFs that were identified as more important also had more recorded interactions in the TRRUST database.