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. 2022 Feb 23;12:3080. doi: 10.1038/s41598-022-07151-1

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© This is a U.S. Government work and not under copyright protection in the US; foreign copyright protection may apply 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Weighted gene co-expression network analysis of proteomic data generated from IMR-90 cells with and without TGFβ treatment. (A) Proteomic Modules Associated with TGFB1 Treatment in IMR-90 cells. Values represent correlation with p-values in parentheses between each module and trait. Heatmap shading corresponds to strength of association where darker red cells have higher upregulation and darker blue cells have higher downregulation based on correlation. Text outlined in yellow denotes result withstands Bonferroni correction for multiple testing based on the number of modules generated. (B,C) Network of hub proteins in proteomic modules significantly associated with TGFβ Treatment. Proteins with a kME larger than 0.90 were selected for visualization in the turquoise (B) and yellow (C) modules. The size of the circle in each network corresponds to increasing module membership and the thickness of the edge corresponds to increasing topological overlap (TOM), a measure of the strength of correlation between protein levels, which is the Pearson’s correlation obtained from the adjacency matrix. Yellow nodes correspond to significant single proteins in the turquoise module associated with TGFβ1 treatment. Red nodes correspond to known targets of pirfenidone and/or nintedanib.