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. 2022 Feb 23;12:3074. doi: 10.1038/s41598-022-05164-4

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Effects of miR-298 on endogenous APP and BACE1 levels in human astrocyte cells. (a,b) Scale drawings of endogenous APP and BACE1 mRNA undefined 3′-UTR with miR-298 binding sites. With full-length 3′-UTR, where miRNAs can bind, miR-298 can reduce APP and BACE1 expression levels. (c,d) Densitometric analysis of APP and BACE1 levels. Each symbol represents a different statistical group. (e) Cell viability determined by CTG assay. (f) Western blotting of APP, BACE1 and β-actin. Results of pairwise comparison of all treatments is shown by symbols. Treatments sharing a symbol did not significantly differ (p < 0.05). "(ns)" indicates no significant pairwise differences.