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. 2022 Feb 23;12:3074. doi: 10.1038/s41598-022-05164-4

Figure 4.

Figure 4

Effects of miR-298 on endogenous APP levels in differentiated neuroblastoma cells. (a) Scale drawing of endogenous APP mRNA undefined 3′-UTR with miR-101 and miR-298 binding sites. Dashed line represents potential truncation or alternation of APP 3′-UTR, where miR-298 binding sites could be absent. (b,c) Densitometric analysis of the blot. (d) Cell viability analysis by CTG assay. (e) Western blotting of APP, BACE1 and β-actin protein. Results of pairwise comparison of all treatments is shown by symbols. Treatments sharing a symbol did not significantly differ (p < 0.05). "(ns)" indicates no significant pairwise differences.