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. 2022 Feb 23;12:3074. doi: 10.1038/s41598-022-05164-4

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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miR-298 treatment’s effect on APP and BACE1 proteins depends on the intrinsic property of each cell type and possible scenarios. (a) Western blot of APP and β-actin proteins. (b) Densitometry analysis. Each symbol represents a different group. (c) Schematic display of potential ways of regulation on APP mRNA 3′-UTR. The miR-298 binding sites on APP 3′-UTR are located downstream of miR-101. Several scenarios that lead to truncated 3′-UTR and could interfere miR-298 binding include alternative polyadenylation sites, presence of SNPs, mutations in miR-298 binding sites and cis-acting elements. Results of pairwise comparison of all treatments is shown by symbols. Treatments sharing a symbol did not significantly differ (p < 0.05). "(ns)" indicates no significant pairwise differences.