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. 2022 Feb 23;12:3056. doi: 10.1038/s41598-022-06848-7

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Fer-1 downregulates ferroptosis markers in MCT-induced PH rats. (A) Representative western blots showing ferroptosis-related proteins (NOX4, GPX4 and FTH1) in total lung homogenates from PH rats 4 weeks after MCT exposure. (B–D) The quantification of protein expression is shown; GAPDH was used as a loading control (37 kDa). The groups of blots were cropped from the same gel. (E) Bar graph showing Fer-1-mediated downregulation of the level of Fe²⁺ in MCT-induced PH rats. The data are shown as the mean ± SD, #P > 0.05 versus the sham group, *P < 0.05 versus the sham group, **P < 0.05 versus the MCT group. n = 8–12/group.