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. 2022 Feb 23;13:1022. doi: 10.1038/s41467-022-28361-1

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 1 — a Topology representation of LtaA. Domain-1 (N-terminal) and domain-2 (C-terminal) are shown in light orange and light blue, respectively. b Individual repeat domains as observed in outward-facing LtaA (PDB ID 6S7V), and superposition of inverted repeats (r.m.s.d. = 2.5 Å and 3.0 Å for aligned Cɑ atoms of R1D1/R2D1 and R1D2/R2D2, respectively). R1D1 and R2D1 indicate the first and second repeats in the N-terminal domain, respectively, whereas R1D2 and R2D2 indicate the first and second repeat in the C-terminal domain, respectively. Colors are according to panel a. c, d Side-views of inward-facing LtaA models generated by “repeat-swap” and by AlphaFold (AF), respectively. The models show TM helices that line the lateral openings. Extracellular and cytoplasmic views are also shown.