Table 2.
Discriminating capability and cut-off values of baseline serum CHIT1 and YKL-40 by ROC curve analysis distinguishing IPF from controls.
| CHIT1 | YKL-40 | |
|---|---|---|
| AUC | 0.806 | 0.788 |
| 95% CI | 0.6231-0.9056 | 0.6118-0.8897 |
| p-value | 0.00001 | 0.00001 |
| Cut-off value | 5.67 nmol/ml/h | 40.90 ng/ml |
| Sensitivity | 75.00% | 68.00% |
| Specificity | 75.00% | 80.00% |
| PPV | 78.26% | 80.95% |
| NPV | 71.43% | 66.67% |
CHIT1, chitotriosidase; YKL-40, chitinase 3-like-1; AUC, area under the curve; CI, confidence interval; PPV, positive predictive value; NPV, negative predictive value.