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. 2022 Feb 10;9:834879. doi: 10.3389/fcvm.2022.834879

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Copyright © 2022 Hockin, Heeney, Whitehurst and Claydon.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Meta-analysis of SF-36 domain scores in patients with VVS and POTS compared to normative data. SF-36 domain scores are shown for patients with VVS (26–30) and POTS (9, 46). Bars represent weighted means and standard deviations for patients with VVS and POTS. Note that the two POTS studies did not report a measure of error; the mean scores from these studies are presented for reference, but have not been included in the statistical analysis. Horizontal line and gray shading denote the mean and standard deviation based on US normative data (n = 2,474) (58). *Significantly different to US normative data at the 0.001 level of significance.