Table 1.
Genome mutations and antimicrobial resistance of F. tularensis strains.
| Strain | Genome positiona | Gene | Amino acid positionb | Amino acid | Codon | Eryc | Cipc | Strc | Rifc |
|---|---|---|---|---|---|---|---|---|---|
| MIC mg/L | MIC mg/L | MIC mg/L | MIC mg/L | ||||||
| FSC201 (AMS) | 316,471 | rpoB | 523 | Serine | TCA | >256 | 0.006 | 2 | 0.38 |
| FSC232 (AMR) | 316,471 | rpoB | 523 | Leucine | TTA | >256 | 0.004 | 1.5 | >32 |
| FSC013 (AMS) | 334,176 | rpsL | 43 | Lysine | AAG | 0.50 | 0.008 | 0.50 | 0.75 |
| FSC016 (AMR) | 334,176 | rpsL | 43 | Arginine | AGG | 0.38 | 0.008 | >1,024 | 0.75 |
a
Position in the FSC201 and FSC013 assembled genomes, respectively.
b
Position in the FSC201 rpoB gene and FSC013 rpsL gene, respectively.
c
Ery, erythromycin, Cip, ciprofloxacin, Str, streptomycin, Rif, rifampicin.