Table 3.
Major F. tularensis cellular functions and pathways influenced by AMR status.
| Pathways/functions with altered protein abundance between AMR and AMS | Directionality | FSC232 vs. FSC201 | FSC016 vs. FSC013 |
|---|---|---|---|
| rpoB mutation (RifR) | rpsL mutation (StrR) | ||
| General lipid metabolism | Up in AMR | 8* | 8 |
| Fatty acid biosynthesis | Up in AMR | 8 | 6 |
| Type 6 secretion system | Down in AMR | 14 | 15 |
| TCA cycle | Up in AMR | 9 | 7 |
| Purine biosynthesis | Up in AMR | 9 | 5 |
| LPS biosynthesis | Up in AMR | 11 | 4 |
| OMPs/OMP processing | Up in AMR | 4 | 6 |
| tRNA ligase | Up in AMR | 8 | 6 |
| Type 4 pili | Up in AMR | 1 | 4 |
*
Number of proteins in each pathway that were observed to be significantly differently expressed.