Table 5.
Antimicrobial resistance-conferring proteins encoded on the Y. pestis MDR plasmid pIP1202 that were observed in this study and their differential expression in the presence of streptomycin.
| Locus ID | Protein description | Confers resistance to: | Differential expression when streptomycin was present in the growth media? | |
|---|---|---|---|---|
| Early | Late | |||
| YpIP275_pIP1202_0175 | Beta-lactamase SHV-1 | Ampicillin | No | No |
| YpIP275_pIP1202_0063 | Chloramphenicol acetyltransferase | Chloramphenicol | No | No |
| YpIP275_pIP1202_0055 | Streptomycin resistance protein A | Kanamycin | No | Yes |
| YpIP275_pIP1202_0190 | Aminoglycoside 3”-adenylyltransferase | Streptomycin and spectinomycin | Yes | Yes |
| YpIP275_pIP1202_0188 | Dihydropteroate synthase (Sul1) | Sulfamethoxazole | Yes | No |
| YpIP275_pIP1202_0073 | Dihydropteroate synthase (Sul2) | Sulfamethoxazole | Yes | Yes |