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. 2022 Feb 10;12:812655. doi: 10.3389/fonc.2022.812655

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Copyright © 2022 Yan, Da, Li, Lin, Yi, Su, Yu, Ren, Liu, Lin, Qu, Yin and Liu

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Expression of NEK7 and GSDMD in hepatocellular carcinoma tissues and cell lines. (A, B) mRNA expressions of NEK7 and GSDMD were significantly upregulated in tumor tissues compared to tumor-adjacent normal tissues. (C) mIHC staining of NEK7 (green) and GSDMD (red) on HCC specimens. Scale bar = 100 μm. (D) Co-locolization between NEK7 and GSDMD was observed on serial sections of HCC specimens. Scale bars = 100 μm. (E) NEK7 mRNA expression in HCC cell lines. (F) GSDMD mRNA expression in HCC cell lines. (G) NLRP3 mRNA expression in HCC cell lines. mRNA expression was normalized by β-actin expression. Error bar, error value in triplicate. (H) Protein expressions of NEK7, GSDMD, and NLRP3 in HCC cell lines.