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. 2022 Feb 10;12:812655. doi: 10.3389/fonc.2022.812655

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Copyright © 2022 Yan, Da, Li, Lin, Yi, Su, Yu, Ren, Liu, Lin, Qu, Yin and Liu

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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NEK7 decreased HCC tumor formation in a splenic xenograft mouse model. (A) Scheme of the xenograft experiment. Female nude mice were intrasplenic transplanted with MHCC97L cells and randomized divided into 2 groups (n = 5/group). 6 weeks after implantation, mice were sacrificed and liver tumors were harvested. (B, C) Downregulation of NEK7 decreased liver weight (p < 0.01) and volume (p < 0.05) of mice. (D) Gross pathology showed that knockdown of NEK7 significantly reduced liver metastasis formation (arrowheads: metastasis lesions). (E) H&E and IHC staining revealed decreased expression of Ki67 and p-ERK1/2 in livers of shNEK7 xenograft mice. *P < 0.05.