FIGURE 2.

(A) Seven-day schematic schedule of BALB/c mice model of sickness behavior and treatment. Five groups of 8-week-old BALB/c mice were exposed to Con-A (10 mg/kg body weight) to induce sickness behavior followed by subsequent pharmacological treatment. Behavior tests were performed on day 2 followed by histopathological analysis of the brain sections. (B) Grouping of mice was done on the basis of pharmacological treatment. Control group was given IP injection of saline (10 ml/kg body weight). The rest of the groups were injected with Con-A and after 30 min were treated with respective pharmacological treatments of fluoxetine, diosgenin, blank SLNP, and diosgenin SLNP (10 ml/kg body weight).