Table 5.
Microscopic findings in SHRSP of both sexes given SOY or CAN diet for 8 weeks.
| Organs | Findings | Male |
Female |
||
|---|---|---|---|---|---|
| SOY | CAN | SOY | CAN | ||
| Brain | Infarction or laminar necrosis of cortex | 2 | 3 | 0 | 0 |
| Glial reaction, microglia or astroglia | 1 | 1 | 0 | 0 | |
| Degeneration of corpus callosum | 1 | 0 | 0 | 0 | |
| Petechial hemorrhaging | 4 | 0 | 0 | 0 | |
| Heart | Myocardium degeneration | 3 | 7 | 0 | 0# |
| Perisclerosis of arterioles | 5 | 9 | 0‡ | 0# | |
| Thrombosis in arterioles | 3 | 7 | 0 | 0# | |
| Lung | Alveolar hemorrhage/congestion | 3 | 3 | 0 | 0 |
| Macrophage infiltration | 2 | 1 | 0 | 0 | |
| Spleen | White pulp atrophy | 1 | 2 | 0 | 0 |
| Arterial wall thickening | 6 | 7 | 0‡ | 0# | |
| Liver | Centrilobular single cell necrosis | 5 | 7 | 0‡ | 0# |
| Microgranuloma | 5 | 6 | 1 | 0# | |
| Periportal fatty change | 6 | 3 | 7 | 2 | |
| Perisclerosis of arterioles | 0 | 3 | 0 | 0 | |
| Kidney | Basophilic tubule | 10 | 10 | 0‡ | 2 |
| Hyalin cast | 5 | 9 | 0‡ | 0# | |
| Glomerular degeneration | 9 | 10 | 1‡ | 0# | |
| Testis | Lymphocyte perivascular infiltration | 0 | 3 | – | – |
| Seminiferous tubule atrophy | 0 | 1 | – | – | |
| Leydig cell atrophy | 0 | 1 | – | – | |
| Epididymis | Cell debris in lumen | 0 | 5* | – | – |
| Uterus | Squamous cell metaplasia | – | – | 1 | 0 |
SOY, 10 w/w% soybean oil diet (control); CAN, 10 w/w% canola oil diet.
Values are means ± SEMs of 10 animals.
‡, Significantly different from the male animals given SOY diet.
#, Significantly different from the male animals given CAN diet.
*, Significantly different from the SOY group in the male animals (p<0.05, Fisher’s exact probability test).