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. 2022 Feb 10;10:814194. doi: 10.3389/fped.2022.814194

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Copyright © 2022 Teofili, Papacci, Bartolo, Molisso, Orlando, Pane, Giannantonio, Serrao, Bianchi, Valentini, Pellegrino, Baldascino, Carducci, Lepore and Vento.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Cumulative transfusion-free survival in a cohort of 72 transfused neonates, grouped according to the occurrence of stage 3 or higher retinopathy of prematurity (ROP). (A) Transfusion-free survival estimated according to postnatal day at first RBC transfusion does not significantly differ between patients with and without severe ROP. (B) Transfusion-free survival estimated according to postmenstrual age at first transfusion is significantly lower in neonates developing severe ROP. (C) The difference between groups is even greater if survival to the second RBC transfusion event is considered. RBC, red blood cell.