Table 2.

Univariate analysis of clinical and transfusion data in neonates with and without severe ROP.

	Severe ROP group n = 25	No severe ROP group n = 47	p-value
Gestational age at birth	25.9 (24.6–27.5)	28.0 (27.0–29.0)	<0.001
Male gender	12 (33.3)	24 (66.7)	1.000
Twin	7 (43.8)	9 (56.3)	0.392
Birth weight, g	710 (615–937)	980 (735–1,210)	0.003
Birth weight percentile	55.8 (7.4–72.1)	52.0 (19.0–69.8)	0.953
SGA	6 (24.0)	11 (23.4)	1.000
Hct at birth, %	48.0 (41.0–50.0)	45.0 (42.0–50.0)	0.593
Apgar score 1m	5 (4–6)	6 (5–7)	0.007
Apgar score 5m	7 (6.−8)	8 (8–9)	0.020
Patent ductus arteriosus*	19 (76.0)	27 (57.4	0.133
Intraventricular hemorrhage	13 (52.0)	21 (44.7)	0.624
Documented infections	13 (52.0	21 (44.7)	0.624
Surgical necrotizing enterocolitis	4 (16.0)	2 (42.5)	0.173
Bronchopulmonary dysplasia	13 (54.2)	11 (45.8)	0.019
Invasive ventilation, days	12.0 (5.0–25.3)	1.0 (0.0–6.0)	<0.001
Non-invasive ventilation, days	45.0 (31.5–88.0)	29.0 (16.0–52.0)	0.044
Oxygen supplementation, days	62.0 (32.0–95.5)	13.0 (1.0–6.01)	0.002
RBC units	6 (3–10)	2 (1–4)	<0.001
Postnatal day at first RBC unit	5 (2–11)	11 (3–22)	0.098
PMA at first RBC unit	26.9 (25.4–29.2)	29.6 (28.4–31.4)	<0.001
Two or more RBC units	24 (96.0)	32 (68.1)	0.007
PMA at second RBC unit	28.3 (26.2–29.2)	30.2 (28.7–34.6)	0.002
PLT transfusion	10 (41.7)	13 (58.3)	0.302
FFP transfusion	5 (55.6)	3 (44.4)	0.116

Data are expressed as n (%) for categorical variables and median (IQR) for continuous variables.

Htc, central venous hematocrit values; RBC, red blood cell; PLT, platelets; FFP, fresh frozen plasma; ROP, retinopathy of prematurity; SGA, small for gestational age; PMA, postmenstrual age; IQR, interquartile range.

^*Patients with hemodynamically significant patent ductus arteriosus are indicated.