Figure 5.

Antiarrhythmic action of I3C. (A) Representative ECG traces of the last 2 s of ischemia and the first 2 min of reperfusion. Lower case letters indicate the beginning of corresponding trace in an augmented time scale. Samples of ventricular tachycardia (VT) and ventricular fibrillation (VF) are indicated and premature ventricular complex (PCV) pointed by black arrows (B) VT and VF in white and black columns quantified a proarrhythmic response in SHR hearts and a marked anti-fibrillatory effect of I3C. (C) The evolution and severity of arrhythmias during the ischemia/reperfusion protocol presented a persistent increase in the SHR group that was prevented by I3C. ∗p < 0.05, ∗∗p < 0.01 vs WKY; and ###p < 0.001 vs SHR.