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. 2022 Feb 10;15:835448. doi: 10.3389/fnmol.2022.835448

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Copyright © 2022 Li, Liu, Kaefer, Youssef and Zhao.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Cisplatin dose-dependently kills wild-type murine hair cells. (A) Cochlear explants were dissected from P3 wild-type C57/BL6J mice and cultured overnight in DMEM/F12 culture medium. Then, the cochlear explants were exposed to cisplatin at different concentrations for 2 days. The samples were fixed and labeled with an antibody against β2-spectrin, a hair cell marker. Note, OHCs (arrowheads) were more susceptible to cisplatin than IHCs (arrows). Scale bar: 10 μm. (B) Numbers of hair cells per 100 μm (3 mice per group). Data are represented as the mean ± standard error (SE). Two-way ANOVA followed by Bonferroni post hoc test was performed (^**p < 0.01 and ^***p < 0.001).