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. 2022 Feb 10;15:835448. doi: 10.3389/fnmol.2022.835448

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Copyright © 2022 Li, Liu, Kaefer, Youssef and Zhao.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Cimetidine protects Tmie^–/– hair cells from cisplatin ototoxicity. (A) Cochlear explants were dissected from P3 Tmie^–/– mice and then exposed to cisplatin at the indicated doses with/without 1 mM cimetidine for 2 days. The samples were fixed and labeled with an antibody against β2-spectrin. Note, cimetidine protected the Tmie mutant hair cells from cisplatin ototoxicity. Scale bar: 10 μm. (B) Numbers of hair cells per 100 μm in the middle region of cochlea (5 mice per group, 50 μM cisplatin; 4 mice per group, 70 μM cisplatin; 3 mice per group, 100 μM cisplatin; 3 mice per group, 120 μM cisplatin). Data are represented as the mean ± SE. ^***p < 0.001 by Student’s t-test.