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. 2022 Feb 10;14:791971. doi: 10.3389/fnagi.2022.791971

TABLE 3.

Association between depressive symptoms and incidence of frailty.

HR (95% CI)
Per SD increase
Normal Depression
Frailty index
Unadjusted 1 (Reference) 1.17 (0.98–1.39) 1.06 (0.996–1.12)
Model 1 1 (Reference) 1.15 (0.96–1.37) 1.05 (0.99–1.11)
Model 2 1 (Reference) 1.18 (0.98–1.41) 1.06 (0.99–1.13)
Phenotypic frailty
Unadjusted 1 (Reference) 1.47 (0.95–2.28) 1.33 (1.17–1.53)
Model 1 1 (Reference) 0.98 (0.63–1.52) 1.14 (0.995–1.31)
Model 2 1 (Reference) 0.96 (0.61–1.50) 1.12 (0.96–1.29)

CI, confidence interval; HR, hazard ratio; SD, standard deviation. The crude model was conducted without any adjustment; Model 1 was adjusted for age, and sex; Model 2 was additionally adjusted for education level, smoking status, alcohol consumption, marital status, place of residence, income, participation in social activities, number of chronic diseases, retirement status, and sleep duration.