Graphical Abstract.

In Brief. Schematic effects of inhibition of HDAC isoforms on production of IL-6 and the anti-AChR autoantibody in MG. Deacetylation-mediated activation of specific histone leads to the activation of genes and signaling pathways that induce IL-6 expression in MG. Conversely, inhibition of histone deacetylation through activation of negative regulators of IL-6 transcription, leads to the repression of IL-6 transcript levels that results in reduced activation of B cells, low levels of autoantibody, and disease improvement.