Table 1.
Significantly up-/down regulated selective genes relative to baseline in the Volcano plot of (H-i)-treated spleen 4 wks post 3rd treatment, +, more prominently down- or up regulated; -, less prominent.
| Downregulated (↓) genes | Function | H-i 1 | H-i 2 |
|---|---|---|---|
|
Birc 2 (IAP-2) (NM_007465.2) |
Inhibitor of apoptosis | + | - |
| H2-Ob (NM_010389.3) | Histocompatibility 2, located in MHC Class II region | + | - |
| IL6ra (NM_010559.2) | Subunit of IL6R, binds to IL6 with low affinity | + | - |
| Rac 1 (NM_009007.2) | Pleiotropic function, upregulate glycolysis and Pentose pathways | + | + |
| Cdk9 (NM_130860.3) | Critical for Polymerase II transcription initiation, elongation/termination | + | - |
| Nfatc1 (NM_016791.4) | Controls transcription of genes that directs cytotoxic effector function of CD8+ T cells | + | - |
| Brwd 1 (NM_001103179.1) | Transcriptional activator | + | - |
| Plcg 1 (NM_021280.3) | Phospholipase C, Gamma, overexpressed in cancer, role in cytoskeleton, cell migration | - | + |
| Csf2 (NM_009969.4) | Controls production, differentiation, and function of granulocytes | - | + |
| Dyn II (NM_026556.4) | GTP binding protein, involved with cell motility | - | + |
| Upregulated (↑) genes | |||
| ISG20 (NM_020583.5) | Interferon-stimulated gene 20, single-stranded RNA exonuclease | + | - |
| Kif 22 (NM_145588.1) | Inhibitor of cell proliferation | + | - |
| F13a 1 (NM_001166391.1) | Encodes for a coagulation factor | - | + |
| IkZf3 (NM_011771.1) | Controls differentiation of lymphoid progenitor cells in to pre T and pre B cells | - | + |