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. 2022 Feb 10;10:836984. doi: 10.3389/fbioe.2022.836984

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Copyright © 2022 Yee, Dickson, Muntasir, Ma and Marsh.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Ovarian cancer histotypes and gene mutations. Epithelial ovarian cancers constitute approximately 90% of all malignant ovarian tumors and are made up of different histotypes: high-grade serous ovarian cancer (HGSOC), endometrioid ovarian cancer (EnOC), ovarian clear cell carcinoma (OCCC), low-grade serous ovarian cancer (LGSOC) and mucinous ovarian cancer (MOC). Ovarian carcinosarcomas (OCS)/malignant mixed mullerian tumors (MMMT) have epithelial and mesenchymal components. Stromal cell tumors include granulosa cell tumors (GCT, adult and juvenile) as well as Sertoli-Leydig cell tumors (SLCTs). Small cell carcinoma of the ovary, hypercalcemic type (SCCOHT) are a rare histotype. Gene mutations, copy number amplifications, methylation and other epigenetic silencing are noted against histotypes.