. 2022 Feb 10;10:836984. doi: 10.3389/fbioe.2022.836984

TABLE 1.

Ovarian cancer cell line origin, in vivo growth and classifications.

Cell line	OvCa Histotype	Specimen site	Growth in vivo in mice	Commercial availability	References
CaOV-3	HGSOC ^a ^, ^b ^, ^d	Ovary tumor	Yes: IP; No: SC, IB	ATCC	Buick et al. (1985) ^f ; Hernandez et al. (2016) ^g
CaOV-4	HGSOC ^a ^, ^c ^, ^d	Fallopian tube metastasis	Yes: SC, IP, IB	ATCC	Hernandez et al. (2016) ^g
COV318	HGSOC ^a ^, ^d ^, ^e	Ascites	No: SC, IP	ECACC	van den Berg-Bakker et al. (1993) ^f ; De Haven Brandon et al. (2020) ^g
COV362^**	HGSOC ^a ^, ^d	Pleural effusion	Yes: IP, forms ascites and IB; No: SC	ECACC	van den Berg-Bakker et al. (1993) ^f ; De Haven Brandon et al. (2020) ^g
KURAMOCHI	HGSOC ^a ^, ^b ^, ^d	Ascites	Yes: SC; No: IP, IB	JCRB	Motoyama (1981) ^f ; De Haven Brandon et al. (2020) ^g
OAW28	HGSOC ^a ^, ^d	Ascites	Unknown	ECACC	Wilson et al. (1996)
OV202	HGSOC	Primary tumor	Unknown	No	Conover et al. (1998) ^f
OVCAR-3	HGSOC ^a ^, ^b ^, ^d ^, ^e	Ascites	Yes: SC, IP	ATCC	Hamilton et al. (1983) ^f ; Hernandez et al. (2016) ^g , De Haven Brandon et al. (2020) ^g
OVCAR-4	HGSOC ^a ^, ^d	Ascites	Yes: SC, IP; No: IB	MERCK Millipore	Pirker et al. (1985) ^f ; Hernandez et al. (2016) ^g ; De Haven Brandon et al. (2020) ^g
OVKATE	HGSOC ^a ^, ^d ^, ^e	Solid metastasis	Yes: SC, IP	JCRB	Yanagibashi et al. (1997) ^f ^, ^g ; Mitra et al. (2015b) ^g
OVSAHO	HGSOC ^a ^, ^d ^, ^e	Solid metastasis	Yes: SC; Yes: IP, forms ascites	JCRB	Yanagibashi et al. (1997) ^f ^, ^g ; De Haven Brandon et al. (2020) ^g
PEO1	HGSOC ^c	Ascites	No	ECACC	Langdon et al. (1988) ^f ; Hernandez et al. (2016) ^g
PEO4	HGSOC ^c	Ascites	No	ECACC	Langdon et al. (1988) ^f , Hernandez et al. (2016) ^g
UWB1.289	HGSOC ^c	Ovary tumor	No: SC, IP	ATCC	DelloRusso et al. (2007) ^f ; Mitra et al. (2015b) ^g
UWB1.289 + BRCA1	HGSOC ^c	Ovary tumor	Unknown	ATCC	DelloRusso et al. (2007) ^f
A2780^*	EnOC ^a ^, ^b ^, ^c ^, ^d	Tumor tissue	Yes: SC and IP, forms ascites	ECACC	Behrens et al. (1987) ^f ; Hernandez et al. (2016) ^g
TOV-112D	EnOC ^b ^, ^d ^, ^e	Ovary tumor	Yes: IP; No: SC	ATCC	Provencher et al. (2000) ^f ; Hernandez et al. (2016) ^g
OVISE	OCCC ^a ^, ^b ^, ^d ^, ^e	Solid pelvic metastasis	Yes: SC; No: IP	JCRB	Gorai et al. (1995) ^f ; Yanagibashi et al. (1997) ^f ^, ^g
OVMANA	OCCC ^a ^, ^b ^, ^d ^, ^e	Primary tumor	Yes: SC; No: IP	JCRB	Yanagibashi et al. (1997) ^f ^, ^g
OVTOKO	OCCC ^a ^, ^b ^, ^d ^, ^e	Solid splenic metastasis	Yes, SC; Yes: IP	JCRB	Gorai et al. (1995) ^f ; Yanagibashi et al. (1997) ^f ^, ^g
RMG-I	OCCC ^a ^, ^d ^, ^e	Ascites	Yes: SC	JCRB	Nozawa et al. (1991) ^f ; Kashiyama et al. (2014) ^g
TOV-21G	OCCC ^a ^, ^b ^, ^d ^, ^e	Ovary tumor	Yes: SC	ATCC	Provencher et al. (2000) ^f ; Kashiyama et al. (2014) ^g
MCAS	MOC ^b ^, ^e	NS	Yes: SC	JCRB	Kidera et al. (1985) ^f ; Sato et al. (2012) ^g
RMUG-S	MOC ^d ^, ^e	Ascites	Yes: SC, IP	JCRB	Sakayori et al. (1990) ^f ; Sato et al. (2012) ^g ; Matsuo et al. (2011) ^g
KGN	GCT	Tumor tissue	Unknown	RIKEN BRC	Nishi et al. (2001) ^f
COV434^***	SCCOHT	Primary tumor	Unknown	No	van den Berg-Bakker et al. (1993) ^f ; Karnezis et al. (2021)

Note: Cell lines identified with >50 publications via PUBMED, on 10/12/2021.

OvCa, Ovarian Cancer; NS, Not specified; ATCC, American Type Culture Collection; JCRB, Japanese Cancer Research Resources Bank; ECACC, European Collection of Authenticated Cell Cultures; RIKEN BRC, RIKEN, BioResource Center Cell Bank; SC, subcutaneous; IP, intraperitoneal; IB, intrabursal.

Originally classified HGSOC,

^**

Originally classified EnOC,

^***

Originally classified as a GCT (Granulosa Cell Tumor),

Recent classification of histotypes.

Domcke et al. (2013),

Anglesio et al. (2013),

Beauford et al. (2014),

Barnes et al. (2021),

Papp et al. (2018).

Original histotype reference,

in vivo tumour growth in mice reference.

EnOC, Endometrioid Ovarian Cancer; OCCC, Ovarian Clear Cell Carcinoma; MOC, Mucinous Ovarian Cancer; HGSOC, High Grade Serous Ovarian Cancer; SCCOHT, Small Cell Carcinoma of the Ovary, Hypercalcemic Type.