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. 2022 Feb 10;12:801094. doi: 10.3389/fphar.2021.801094

FIGURE 1.

FIGURE 1

C. cicadae alleviated SHR renal injury and fibrosis. (A) H&E staining (bar = 100 μm) and Masson’s trichrome staining (bar = 40 μm). (B) C. cicadae treatment significantly decreases ACR levels after 14 and 28 weeks. (C) C. cicadae treatment significantly downregulates β2-MG expression after 14 and 28 weeks. (D) C. cicadae treatment significantly reduced β2-MG level at the 28th week. (E) The representative images and statistical graph of IHC staining for α-SMA (×200). Bar = 100 μm. Apoptosis in rat renal tubules of various groups was evaluated by TUNEL assay. Scale bar: 40 μm. (F) Effect of C. cicadae and RES on TGFβ1, α-SMA, FN, and Col-1 expression. (G–J) The relative intensities of fibrosis-related protein in kidneys were calculated after normalization against GAPDH. Data were presented as mean ± SD, n = 10 rats per group. For the WKY group vs the SHR group, #p < 0.05, ##p < 0.01. For the SHR group vs the C. cicadae group, *p < 0.05, **p < 0.01. N.S. No significance.