Table 2.
Correlation Analysis Between NUTF2 and Related Genes and Markers of Immune Cells in TIMER
| Description | Gene Markers | HNSC | |||||
|---|---|---|---|---|---|---|---|
| None | Purity | Age | |||||
| Cor | P | Cor | P | Cor | P | ||
| CD8 + Tcell | CD8A | −0.346 | 0.000 | −0.277 | 0.000 | −0.066 | 0.134 |
| CD8B | −0.358 | 0.000 | −0.242 | 0.000 | 0.071 | 0.105 | |
| T cell (general) | CD3D | −0.300 | 0.000 | −0.298 | 0.000 | 0.047 | 0.282 |
| CD3E | −0.346 | 0.000 | −0.299 | 0.000 | 0.047 | 0.285 | |
| CD2 | −0.331 | 0.000 | −0.285 | 0.000 | 0.063 | 0.183 | |
| B cell | CD19 | −0.313 | 0.000 | −0.261 | 0.000 | −0.018 | 0.678 |
| CD79A | −0.365 | 0.000 | −0.228 | 0.000 | −0.022 | 0.616 | |
| Monocyte | CD86 | −0.083 | 0.058 | −0.295 | 0.000 | 0.057 | 0.193 |
| CSF1R | −0.169 | 0.000 | −0.304 | 0.000 | 0.075 | 0.088 | |
| TAM | CCL2 | −0.108 | 0.014 | −0.258 | 0.000 | 0.108 | 0.013 |
| CD68 | −0.044 | 0.317 | −0.172 | 0.000 | 0.013 | 0.766 | |
| IL10 | −0.058 | 0.189 | −0.313 | 0.000 | −0.034 | 0.440 | |
| M1 Macrophage | NOS2 | −0.320 | 0.000 | 0.071 | 0.116 | 0.040 | 0.357 |
| IRF5 | −0.255 | 0.000 | −0.001 | 0.975 | 0.021 | 0.638 | |
| PTGS2 | 0.045 | 0.302 | 0.100 | 0.027 | −0.079 | 0.073 | |
| M2 Macrophage | CD163 | −0.067 | 0.128 | −0.286 | 0.000 | 0.111 | 0.011 |
| VSIG4 | −0.018 | 0.684 | −0.257 | 0.000 | 0.119 | 0.001 | |
| MS4A4A | −0.041 | 0.354 | −0.287 | 0.000 | 0.101 | 0.021 | |
| Neutrophils | CEACAM8 | −0.161 | 0.000 | 0.034 | 0.448 | −0.010 | 0.824 |
| ITGAM | −0.267 | 0.000 | −0.137 | 0.000 | 0.072 | 0.100 | |
| CCR7 | −0.360 | 0.000 | −0.322 | 0.000 | −0.031 | 0.478 | |
| Natural killer cell | KIR2DL1 | −0.144 | 0.000 | −0.093 | 0.038 | −0.016 | 0.716 |
| KIR2DL3 | −0.189 | 0.000 | −0.136 | 0.000 | 0.028 | 0.521 | |
| KIR2DL4 | −0.235 | 0.000 | −0.183 | 0.000 | 0.111 | 0.011 | |
| KIR3DL1 | −0.284 | 0.000 | −0.144 | 0.000 | −0.002 | 0.959 | |
| KIR3DL2 | −0.316 | 0.000 | −0.147 | 0.000 | −0.008 | 0.863 | |
| KIR3DL3 | −0.142 | 0.000 | −0.086 | 0.057 | −0.066 | 0.133 | |
| KIR2DS4 | −0.134 | 0.000 | −0.148 | 0.000 | 0.036 | 0.414 | |
| Dendritic cell | HLA-DPB1 | −0.256 | 0.000 | −0.302 | 0.000 | 0.079 | 0.073 |
| HLA-DQB1 | −0.186 | 0.000 | −0.228 | 0.000 | 0.062 | 0.159 | |
| HLA-DRA | −0.252 | 0.000 | −0.299 | 0.000 | 0.072 | 0.099 | |
| HLA-DPA1 | −0.235 | 0.000 | −0.285 | 0.000 | 0.075 | 0.087 | |
| CD1C | −0.283 | 0.000 | −0.257 | 0.000 | −0.048 | 0.272 | |
| Th1 | NRP1 | 0.070 | 0.110 | −0.207 | 0.000 | 0.054 | 0.218 |
| ITGAX | −0.129 | 0.000 | −0.283 | 0.000 | 0.092 | 0.035 | |
| TBX21 | −0.304 | 0.000 | −0.244 | 0.000 | 0.079 | 0.070 | |
| STAT1 | −0.080 | 0.067 | −0.240 | 0.000 | 0.040 | 0.361 | |
| IFNG | −0.251 | 0.000 | −0.234 | 0.000 | 0.125 | 0.000 | |
| TNF | 0.053 | 0.231 | −0.127 | 0.000 | −0.114 | 0.001 | |
| Th2 | GATA3 | −0.099 | 0.023 | −0.227 | 0.000 | 0.031 | 0.474 |
| STAT6 | −0.168 | 0.000 | 0.069 | 0.126 | 0.074 | 0.090 | |
| STAT5A | −0.284 | 0.000 | −0.132 | 0.000 | −0.007 | 0.882 | |
| IL13 | −0.185 | 0.000 | −0.154 | 0.000 | 0.130 | 0.000 | |
| Tfh | BCL6 | −0.208 | 0.000 | 0.175 | 0.000 | −0.020 | 0.644 |
| IL21 | −0.348 | 0.000 | −0.175 | 0.000 | 0.065 | 0.139 | |
| Th17 | STAT3 | −0.370 | 0.000 | −0.017 | 0.708 | −0.037 | 0.405 |
| IL17A | −0.274 | 0.000 | −0.102 | 0.024 | 0.011 | 0.811 | |
| Treg | FOXP3 | −0.276 | 0.000 | −0.253 | 0.000 | 0.006 | 0.896 |
| CCR8 | −0.268 | 0.000 | −0.234 | 0.000 | 0.011 | 0.810 | |
| STAT5B | −0.164 | 0.000 | −0.051 | 0.256 | 0.036 | 0.413 | |
| TGFB1 | 0.266 | 0.000 | −0.142 | 0.000 | 0.004 | 0.935 | |
| T cell exhaustion | PDCD1 | −0.295 | 0.000 | −0.268 | 0.000 | 0.076 | 0.082 |
| CTLA4 | −0.186 | 0.000 | −0.310 | 0.000 | 0.029 | 0.509 | |
| LAG3 | −0.157 | 0.000 | −0.237 | 0.000 | 0.083 | 0.059 | |
| HAVCR2 | −0.140 | 0.000 | −0.277 | 0.000 | 0.084 | 0.056 | |
| GZMB | −0.216 | 0.000 | −0.264 | 0.000 | 0.098 | 0.025 | |