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. 2022 Feb 10;12:836517. doi: 10.3389/fonc.2022.836517

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Copyright © 2022 Pu, Liu, Zhou, Chen, Hou, Cai, Chen, Wu, Yang, Tan, Yin, Wang and Cao

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Effects of HBx combo mutations on HCC occurrence in a prospective cohort study with 2114 HBV-infected patients. (A) Effect of A1762T/G1764A+C1653T+T1674G on HCC occurrence. (B) Effect of A1762T/G1764A+T1674G+T1753C on HCC occurrence. (C) Effect of A1762T/G1764A+C1653T+T1753C on HCC occurrence. Hazard ratio (HR) was adjusted with age and gender.